WP3 - Adrenal cancer pathology platform

Objectives

Establishment of a tissue micro-array of adrenomedullary and adrenocortical tumours to facilitate high-throughput validation of newly identified prognostic markers
Implementation of SDHB immunohistochemistry to guide genetic analysis of phaeochromocytomas
Establishment of vascular pattern analysis for the prediction of clinical behaviour in phaeochromocytomas
Improvement of current classification systems for the prediction of clinical behaviour in adrenocortical tumours
Validation of previously established diagnostic and prognostic markers for risk stratification of adrenocortical tumours
Establishment of novel immunohistochemical markers derived from genomics approaches to predict clinical behaviour of adrenocortical and adrenomedullary tumours