University of Florence

University of Florence 

University of Florence
Viale Pieraccini 6
50139 Firenze
Italy

http://www.unifi.it

Principal Investigator

Prof. Massimo Mannelli

Prof. Massimo Mannelli

Phone +39-055-4271428

contact

Project Staff

Prof. Michaela Luconi

Prof. Michaela Luconi
Associate Professor

Phone +39-055 4271369
Fax +39-055 4271371

contact

Dr. Giada Poli
PhD student

Dr. Monica Mangoni
Researcher

Dr. Tonino Ercolino
Technician

Dr. Giulia Cantini
PhD student

Prof. Gabriella Nesi
Associate Professor

Dr. Michela Francalanci
Post Doc

Dr. Elena Rapizzi
Post Doc

Dr. Valentina Piccini
Assistant

Institute Presentation

The Department of Clinical Pathophysiology includes clinical personnel and basic scientists working together on cancer research. Translational research is carried out using its patient cohorts and the laboratory facilities which include cellular and molecular biology, genetic analysis, chemical chemistry and animal models.
Prof. Mannelli’s team of physicians has an established clinical experience in adrenal diseases, including adrenocortical cancer and phaeochromocytoma. Amongst many other, Prof. Mannelli is member of the Soc. Italiana Endocrinologia and of European Society of Endocrinology and has referee positions for numerous journals in the field (J Endocrinol Invest; Eur J Endocrinol; J Clin Endocrinol Metab).
Prof. Luconi’s group possesses a large experience in cell biology, intracellular signalling and proteomics of solid tumours and cell models.
Dr. Mangoni has an established experience in nude mouse xenograft models to be used to test in vivo the antineoplastic effects of the drugs or the combination of drugs previously tested in vitro.

University of Florence will participate in WP2. The main tasks within the project will consist of

  • Identification of the candidate cell signalling pathways underlying progression, proliferation, invasiveness and metastatic potential of ACC which can be potential cellular targets for TZD and MIT
  • Effects of RGZ alone or in combination with MIT compared to mitotane alone on progression, proliferation, invasiveness and metastatic potential of ACC in in vitro cell and in vivo xenograft models